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Topical application (well-studied): Serums at 0.1-0.5%, creams at 0.2-1%, hair products at 0.1-0.3%

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Notably, mPTP opening represents a critical decision point in cell fate: transient, low-conductance openings serve physiological roles in Ca 2+ homeostasis, whereas sustained, high-conductance opening exceeding the point of no return inevitably leads to mitochondrial swelling, outer membrane rupture, and cell death via apoptosis or necrosis (94)

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