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The care paradigm is starting to shift, with the understanding that its beneficial to treat metabolic health conditions before they progress to an advanced stage. The team hopes this new data can help physicians better understand and identify patients who are less likely to access obesity treatment, with challenges ranging from difficulty in obtaining care from obesity medicine practitioners to lack of formulary coverage for weight-management medications

This article begins with an overview of basic pathological mechanisms and offers a comprehensive overview of relevant therapeutic approaches and future development directions, aiming to facilitate the transition of the field from traditional generalized therapies to personalized precision medicine and to bridge the long-standing gap between basic research and clinical practice

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