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Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)

The G-protein beta and gamma subunits (G) subunits downstream of G-protein-coupled receptors (GPCRs), also trigger activation of p110

doi: 10.1016/j.atherosclerosis.2005.08.026