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CNS Drugs 26 , 613636 (2012) Xiong, Y., Mahmood, A

Because tirzepatide typically produces greater total body weight loss than semaglutide, patients on tirzepatide may experience more pronounced facial volume changes than those on semaglutide at comparable timeframes

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Fourth, some health utility data were from studies in other countries due to the lack of local data, which may not fully reflect the situation of the Chinese population

These direct effects are further supported by human studies demonstrating the wide expression of GLP-1 receptors in the proximal tubules, juxtaglomerular cells, hilar and intralobular arteries, and preglomerular vascular smooth muscle cells [49]