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doi: 10.3390/nu14091818 129 HaleLPGreerPKTrinhCTGottfriedMR

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In this review, detailed information on drug-induced kidney injury mechanisms and available in vitro models to predict this with relevant translational biomarkers will be discussed, with an emphasis on novel developments in the field of microphysiological systems that meet the requirements of the 3Rs (replacement, reduction, refinement) of animal experiments for drug safety screenings

de Haan JB, Bladier C, Griffiths P, Kelner M, OShea RD, Cheung NS, Bronson RT, Silvestro MJ, Wild S, Zheng SS, et al