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In its pivotal Phase 3 ATTAIN-1 trial, which involved over 3,000 adults with obesity or overweight, orforglipron demonstrated significantly higher weight loss compared to a placebo

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Some peptides may lose effectiveness or increase the risk of irritation when mixed

Image: Galina Zhigalova/Getty Images About the Author Maureen Salamon, Executive Editor, Harvard Women's Health Watch About the Reviewer Meghan Salamon, MS, RDN, LDN, CPT, Contributor Disclaimer: As a service to our readers, Harvard Health Publishing provides access to our library of archived content