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The MAT2A inhibitor PF-9366, employed to simulate MR, was tested on CRISPR/Cas9-engineered Mixed-Lineage Leukemia (MLL)-AF4and MLL-AF9 fusion gene models, MLL-rearranged (MLLr) cell lines (SEM t(4;11) and THP-1 t(9;11)), and the non-MLLr cell line SKM-1, using healthy cells as controls (50)

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