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3.1 T1D-associated genes: impact on immune function Approximately 40-50% of the genetic risk of developing T1D is attributed to the class I and II MHC/HLA region, with class II being the most significant, as it is essential to the adaptive immune system ( Figure 1 ) ( HLA-DR , HLA-DQ , and HLA-DP loci (58, 59)

Even the type of B12 used in treatment can vary

-20C, 1 month (sealed storage, away from moisture and light) Publications (6) Journal Impact Factor Most Recent Free Radic Biol Med APOE4 impairs Nrf2-PINK1/Parkin-dependent mitochondrial clearance through disrupted antioxidant and mitophagy signaling

Khattab HA, Moselhy SS, Aljafri AO (2020) Olive leaves extract alleviate diabetic nephropathy in diabetic male rats: impact on oxidative stress and protein glycation

Decrements in Vitamin E, ascorbate, -carotene and retinol, while increments in lipid peroxidation were observed

From baseline (week 0) to end of treatment (week 64)