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S.CleareA

It was designed as an agonist of the growth hormone secretory receptor (GHS-R1a) the same receptor that is activated by endogenous ghrelin

Without this substance, lipids could not be broken down, consequently lipolysis would also be discouraged, as the human body is a perfect machine that regulates itself, avoiding metabolic dysfunction

This occurs because the two compounds act through distinct and mechanistically independent receptors (GHRH-R and GHS-R1a respectively), and their downstream signalling cascades converge synergistically at the level of pituitary somatotroph GH secretion

Pi-Sunyer et al., NEJM (2015)

Tolerability - some patients wont accept unpleasant side effects