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The ability of metformin to reduce androgen levels in women with hyperandrogenic PCOS is more pronounced in non-obese women ( The observed changes in total and LDL cholesterol during semaglutide treatment in our cohort were in line with a systematic review and meta-analysis addressing the efficacy and safety of GLP-1 RAs on body weight and cardiometabolic parameters in individuals with obesity and without diabetes and with a systematic review and meta-analysis of semaglutide 2.4 mg including the 2-year STEP 5 trial ( When interpreting the endocrine and cardiometabolic outcomes, it is important to highlight that participants in our cohort were already treated with metformin before the semaglutide intervention, therefore prior the baseline assessment
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When taking GLP-1 agonists, weight
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NF-B, pro-inflammatory cytokines, and VEGF were also shown to be blunted with topical GLP-1 administration in diabetic mice [81]
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