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TB-500 and Actin Biology The Foundational Research Thymosin beta-4 binds and alters the cytoskeletal actin filaments by sequestering actin monomers, influencing actin filament assembly and regulating migration of multiple cell types including endothelial cells, myocardial cells, and epicardial progenitors with Akt activation via the ILK/PINCH/focal adhesion complex pathway confirmed as the primary survival signalling mechanism downstream of its actin-binding activity

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