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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

High dose oral supplementation is an effective alternative to parenteral treatment Randomized studies of daily high oral doses of 1,0002,000 g have shown equivalence or superiority to injected B 12

It also influences insulin regulation, which is crucial for managing body weight and fat storage

How often should I get MIC injections

Clinical Biochemistry 45 (6): 440444