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Insulin-like growth factor 1 (IGF-1) is a polypeptide growth factor that promotes cell proliferation and survival intissues such as muscle, bone, and cartilage

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In the cohort of the 122 malignant peripheral nerve sheath tumors, complete loss of H3K27 trimethylation was observed in 50% of low-grade, 55% of intermediate-grade, and 80% of high-grade tumors

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