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Dosages as high as 9 mg and 10 mg of Mazdutide were trialed and generally well-tolerated with no serious adverse events, achieving a respective placebo-corrected body weight loss of 9.8% and 6.2% in overweight or obese Chinese adults [89]

The parenteral route of administration ensures that the amount of the drug reaches its target site and enables to attain therapeutic effects more efficiently

Ongoing monitoring is important, particularly for blood pressure and kidney function

Ulven SM, Holven KB, Gil A, Rangel-Huerta OD

Toxic epidermal necrolysis and Stevens-Johnson syndrome

195,196 Glutamate in the gut-brain axis Glutamate as the metabolic precursor of GABA is the most abundant excitatory neurotransmitter in the brain