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10.1016/j.fsi.2021.12.005 103 MaX.ChengZ.KongH.WangY.UnruhH.StephensN

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Drug displaced from plasma protein will of course distribute throughout the volume of distribution, so that a 5% increase in the amount of unbound drug in the body produces at most a 5% increase in pharmacologically active unbound drug at the site of action

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