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That fasting window is when the peptide does its work

Taken together, our results indicate that binding of one IGF1 molecule is sufficient to break the autoinhibited state of IGF1R, leading to receptor activation

Cycling off the peptides (e.g., a 4-week break after a 12-week cycle) is crucial for maintaining pituitary sensitivity and ensuring the long-term efficacy of the protocol

Study Duration: Four to six weeks

doi.org/10.3389/fphar.2021.627533 Hsieh, M

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