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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

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Darwesh AM, El-Azab MF, Abo-Gresha NM, El-Sayed NM, Moustafa YM

Australian surveillance data warn that 1,4-BD combined with alcohol may create delayed toxicity, because alcohol can temporarily slow the conversion of 1,4-BD to GHB, leading people to think the dose is weak and re-dose, only to experience a dangerous CNS depressant effect later