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GHIGF-1 axis: Hypothalamus, pituitary, liver, IGF-1, muscle, adipose tissue, and feedback loops

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In addition, pigmentation derived from foreign bodies, heavy metal poisoning or drugs may also promote pigmented lesions, which can vary in intensity and extension, and can occur in any sites of the oral cavity

N-acetylcysteine protects against liver injury induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway