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While traditional paradigms have centered on erythropoietin deficiency and iron dysregulation, it is now evident that accelerated erythrocyte deathdriven by uremic toxins, oxidative stress, chronic inflammation, and iron imbalanceplays a critical role in reducing red blood cell lifespan and exacerbating anemia

Metformin does not directly stimulate insulin release, which makes it a lower-risk option for people concerned about hypoglycemia

Use caution in a patient with a history of angioedema with another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with JANUVIA

Digestive comfort improves through a controlled immune response

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