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Participants who started too high or escalated too quickly in clinical trials experienced nearly double the rate of nausea and vomiting compared to those who followed the gradual protocol

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Both methods were time-consuming, expensive and imprecise (Randle

Advert That's more than Mounjaro, which during clinical trials was found to lead to an average of 26.6 percent weight loss over 84 weeks, and Wegovy, which was found to help patients lose 19 percent of their body weight over 72 weeks

However, some data support initial combination therapy for more rapid attainment of glycemic goals (113,114) and later combination therapy for longer durability of glycemic effect (115)

Moreover, these systems did not address the raising prevalence of obesity in T1D, which is associated with vascular risk and complications 12,13,14