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NORSE and FIRES are defined below: Epilepsia partials continua (EPC) is defined & discussed here: NORSE NORSE definitions New-onset Refractory Status Epilepticus (NORSE) : New-onset seizure with refractory status epilepticus (i.e., refractory to two medications such as benzodiazepine plus levetiracetam)

The mechanism works through beta-3 adrenergic receptors, which are concentrated in fat tissue, particularly around the abdomen and midsection

Your GP will determine the most suitable route based on your individual circumstances

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This serves two purposes: receptor sensitivity maintenance (continuous stimulation can lead to downregulation) and allowing you to assess your baseline before adding another layer of intervention