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Histone deacetylases including SIRT1, interact with STAT3 and negatively regulate its transcriptional activity by deacetylating critical lysine residues (Nie et al., 2009)

This makes it more stable and easier to handle, particularly in manufacturing processes where moisture can impact product quality

doi: 10.3390/ani11020401 87

Furthermore, deletion of Sesn2 intensifies LPS-induced ferroptosis and impairs the ferroptosis and immunological response of DCs after cecal ligation and puncture (74)

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10.1021/mp400664t Mol