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IGF-1 reduces serum GH levels (via somatostatin negative feedback in the pituitary) which in turn suppresses GH actions in the liver, thus enhancing insulin actions in this organ [165]

2021 Dec 3;151(12):360616

Since uremic animals also failed to show increases in GFR and RPF after amino acid infusion, known to enhance kidney function in healthy animals, the authors concluded that the vasodilatory eicosanoids are already maximally stimulated under baseline conditions in uremic animals and, consequently, renal reserve capacity is diminished in these animals

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