Results announced in December 2025 confirmed the Phase 2 findings at a longer timepoint (Lilly Press Release, Dec 2025): The 28.7% weight loss at 68 weeks exceeds both semaglutide (~15% in STEP trials) and tirzepatide (~22.5% in SURMOUNT trials) at similar timepoints
We've done concerts, golf tournaments, outdoor markets and more
In particular, the adverse events of pseudoephedrine are mainly concerning the cardiovascular system, supported by the increased availability of catecholamines and by the subsequent overstimulation of the adrenergic receptors
24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases
The reason 'dose titration,' which involves starting with a small amount and gradually increasing it, is recommended is to minimize side effects
Requires medical consultation and works best with exercise and healthy diet
