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However, the study limitations were noted in the table of data extraction, and discrepancies between studies will be further explored in the Section 4 of the article

For instance, decreased expression of lncRNA H19 increases ROS via the MAPK/ERK signaling pathway (Ding et al., 2018), while the reduction of lncRNA growth arrest specific 5 in melanoma enhances intracellular ROS (Chen et al., 2019)

This mechanism underpins its fibroblast migration-promoting effects and helps explain its capacity to accelerate tissue repair at a cellular motility level independent of proliferation