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Research shows caloric reductions between 16% and 39% depending on the medication and dose

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doi: 10.1016/S0002-9440(10)64328-3 72 BeasleyNJPPrevoRBanerjiSLeekRDMooreJvan TrappenPet al

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These pathways are both serotonergic (eg, rostral ventral medulla) and noradrenergic (eg, dorsolateral pontine tegmentum), converging into the dorsal lateral funiculus, which synapse in rexeds laminae I, II and V in the spinal cord dorsal horn