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Their primary mechanisms of action include: Stimulating insulin secretion in a glucose-dependent manner (reducing hypoglycaemia risk) Suppressing glucagon release when blood glucose is elevated Slowing gastric emptying, which prolongs satiety Acting on appetite centres in the brain to reduce food intake Common GLP-1 medicines available in the UK include semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)

Autoimmune and inflammatory contributions to hair loss operate through different pathways than CXXC5-mediated Wnt suppression

Incorporating Physical Activity Moving your body is non-negotiable if you want to maximize your weight loss

In reality, follow-up after stopping medication is equally important

Finally, we show that the same pharmacological strategies that are efficacious in improving stroke recovery through pre-stroke weight loss (via GLP-1R/NPY2R) can additionally provide acute neuroprotective effects post-stroke, independently of weight loss induction

Many of our patients adopt this approach, finding it motivates them to stay committed to their weight loss goals