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Indeed, when we undertook LCMS analysis of TCA cycle metabolites, ML226 treatment resulted in the accumulation of 2-OG and 2-HG, but this did not occur following DEG treatment, which increased only free glutarate (Fig

The HR-negative hrcC mutant is still capable to elicit the unspecific, symptomless basal resistance response

According to data reviewed by CDER, compounds derived from peptides and proteins show minimal QT prolongation risk because of their natural degradation and targeted action

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