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Active exome sequencing can uncover a variety of mutations in sodium, potassium, and calcium channel genes, in addition to gamma-aminobutyric acid (GABA) and NMDA receptor genes [26,27]

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The prodrug was stable in normal tissues but can be easily hydrolyzed into DON in P493B lymphoma cells, inhibiting tumor cell proliferation in a dose-dependent manner (Tenora et al., 2019)

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