In summary, both GIP and GLP-1 mediate the incretin effect but there is continuing emerging evidence that these hormones modulate physiological responses in extrapancreatic organs
More rigorous and systematic future research is necessary to further elucidate the causality, mechanistic basis, and population differences of this association, ultimately achieving an optimal balance between safety and benefit
[DOI] [PMC free article] [PubMed] [Google Scholar] Graziano MP, Hey PJ, Borkowski D, Chicchi GG, Strader CD
If you have specific concerns about muscle loss or want a personalized treatment plan informed by genetic testing, PlexusDx clinicians can review your individual risk factors and adjust your semaglutide strategy accordingly
Modest weight loss of 5-7% at one year
This imbalance can contribute to diarrhea