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Corticosteroids promote: Fat redistribution , causing central (truncal) obesity and the characteristic "cushingoid" appearance with prolonged use Fluid retention , leading to weight gain that may not reflect true fat accumulation but can be discouraging Muscle protein breakdown , reducing lean body mass and potentially lowering metabolic rate Insulin resistance , making weight loss more difficult The magnitude of these effects is generally dose- and duration-dependent

Dose titration and protocol changes respond to clinical data, not a fixed schedule

The Science Behind Weight Loss with GLP-1 Appetite Regulation By mimicking natural hormones that signal the brain to reduce hunger and increase feelings of fullness, these medications make it easier to eat less

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hence, long-term effects are unsustainable