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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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A deficiency of glutathione leads to increased oxidative stress, which greatly reduces the body's ability to detoxify the accumulation of pollutants and heavy metals

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