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The mechanism is through short-chain fatty acid production from fermentation stimulating peristalsis, and through direct effects some strains have on intestinal transit time

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GLP1 is also produced centrally by neurons in the caudal brainstem, a key integration site for gutbrain signalling pathways which regulate energy homeostasis, particularly those mediated by the vagus nerve (Brierley et al., 2021

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In this respect, more research efforts are essential and needed to minimize the risk of pulmonary aspiration and minimize anesthesia risk during sedated medical procedures in patients on GLP-1 RAs