The study protocol was registered in the International Prospective Register of systematic reviews PROSPERO (CRD420251002447)
Toujeo does carry a somewhat lower hypoglycemia risk compared to Lantus, thanks to its more gradual absorption profile
Nearly all PCOS patients prescribed semaglutide or tirzepatide also had obesity or type 2 diabetes, suggesting use remains primarily tied to metabolic indications, though broader interest in PCOS benefits is growing within scientific literature
In some cases, patients on GLP1 therapy lose lean body mass along with fat
A molecular basis for the effects of metformin on cognitive function is suggested by data using adult murine neural stem cells in culture that shows metformin in the concentration range 500 nM to 1 M enhanced proliferation and self renewal dependent on the transcription factor, Tap73, and enhanced neuronal differentiation via the AMPK-atypical protein kinase C (aPKC)-CREB-binding protein (CBP) pathway [(117): Table 2 ]
Even the pharmaceutical advertising, with images of healthy people living active lives, uses nearly identical visual language for both drug classes
