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Interestingly, we discovered that such decreases in GSH levels during ferroptosis do not occur immediately on erastin treatment, despite dramatic changes in cellular morphology (Fig

Ferroptosis contributes not only to the endocrine and metabolic disturbances in PCOS but also directly to its reproductive impairments

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Second, we discovered a paradoxical relationship between baseline disease severity and treatment response, wherein patients with more severe disease showed higher rates of improvement

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