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61 This poly-agonist escalation allows innovators to continually raise the bar for best-in-class therapy, making it harder for first-generation generics to compete on clinical grounds alone

Elevated levels of 8-OHdG may indicate oxidative stress and, consequently, the progression of MASLD [101, 175]

Prior authorization delays also deter insured patients from accessing these medications

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The researchers note that people previously treated with tirzepatide generally lost more total weight initially, which may partly explain the larger rebound

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