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Currently, another small molecule GLP-1R agonist called compound 29 (DA-302168S) has also shown good therapeutic potential (Dong et al., 2025)

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Disruptions in mitochondrial function lead to increased oxidative stress, cellular damage, and eventual neurodegeneration (Anderson et al., 2023)

doi: 10.3389/fimmu.2018.00455, 16

Given the availability of other hypoglycemic drugs many clinicians avoid the use of DPP-4 inhibitors in these patients