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The study employed rotenone (3 mg/kg/day for 21 days) administered via intraperitoneal injection to establish a rat model of PD, with hydrogen-saturated saline (0.6 mM) applied at different stages (early, middle, late) for treatment

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One randomized double-blind placebo-controlled study found that GHRH analogs, including tesamorelin, increase the concentration of GABA (gamma-aminobutyric acid) and decrease myoinositol levels [7]