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Keywords: antioxidant properties, biological functions, deficiency in thiamine: causes and effects, neuropathy, thiamine, thiamine esters Introduction Vitamin B1, thiamine, is a vitamin with a multidirectional action on the human body and has long been of great interest to doctors, nutritionists and scientists

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Zhou et al., 2007, Metabolism,DOI: 10.1016/j.metabol.2006.10.024

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It is typically administered as a once-weekly subcutaneous injection in clinical studies

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Patients who cannot tolerate 1.2 mg after one week may tolerate it after two or three weeks at 0.6 mg, possibly because GLP-1-driven central appetite suppression adapts over that window

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