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These typically occur in 20-40% of patients and include: Nausea (most common, especially during dose increases) Vomiting Diarrhea Stomach pain Decreased appetite Constipation These side effects usually improve over time as your body adjusts to the medication

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Competitive forces Therapeutic class crowding : multiple GLP-1 RAs and next-gen incretin combinations compete on dose convenience, titration burden, efficacy (A1c and weight), and tolerability

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The mechanisms for GLP-1 mediated diuresis and natriuresis were explained by Crajoinas et al., who reported that these effects were mediated by changes in renal hemodynamics and by downregulation of NHE3 activity in the renal proximal tubule [126]

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