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The lactam bond between positions 145 and 149 was then formed by activation with PyBOP, and the peptide was finally deprotected and cleaved from the resin by treatment with trifluoroacetic acid (TFA)/triisopropylsilane/H 2 O = 95/2.5/2.5 ( v / v / v )

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway

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