Statistical analysis A sample size of 156 participants (104 randomized to survodutide and 52 to placebo) was calculated to provide 90% overall power to demonstrate superiority of survodutide 6.0 mg over placebo for both co-primary endpoints, each at a two-sided significance level of 0.05, assuming an early treatment discontinuation rate of 15%
Frequently Asked Questions Why is adding a DPP-4 inhibitor to a GLP-1 agonist usually redundant
While selenium is essential, excessive intake above 400mcg daily long-term can cause selenosis (selenium toxicity), with symptoms including hair loss, nail brittleness, nausea, and fatigue
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Bokar, J
This systematic review and meta-analysis aim to synthesize current evidence on how GLP-1 RAs influence testosterone levels and highlight areas for future investigation