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In the SURPASS clinical trials for type 2 diabetes, patients achieved A1c reductions ranging from 1.9% to 2.4% at the highest doses by week 40

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Emerging preclinical and clinical evidence suggests these medications may modulate reward-seeking behaviour and reduce the reinforcing effects of alcohol, though this remains an area of active investigation rather than established clinical practice

The mean changes from baseline to week 26 were -0.9 kg and -3.4 kg in the placebo and RYBELSUS 14 mg arms, respectively

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In the multivariable Cox regression analysis, cardiovascular disease (hazard ratio [HR] 2.732, P = 0.037), rectal wall V 65 (HR 1.158, P = 0.027), and VRS 3 in first post-radiotherapy endoscopy (HR 2.573, P = 0.031) were significant risk factors for rectal bleeding