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The highest dose group achieved average reductions of around 20% of body weight

N Engl J Med 392(6):612615 [DOI] [PubMed] [Google Scholar] 28.Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, Thomas MK, Hartman ML, Haupt A, Milicevic Z, Coskun T (2023) Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

Delayed stomach emptying can cause nausea, vomiting, constipation, or heartburn, especially when starting the medication or increasing the dose

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