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Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases

If the water has frozen, let the bottle thaw before trying again from the beginning

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RR 1.8, 95% CI: 1.2 to 2.7)

These sensations occur when blood vessels near the skin surface dilate suddenly, bringing more blood to the surface and releasing heat

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