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The divergent outcomes reflect participant selection: Zepbound enrolled obese individuals without mandatory diabetes, while Ozempic prioritized glycemic improvement in existing diabetic populations

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As a result, sugar builds up in the blood instead of being used for energy

Specifically, we hypothesized to find increased reward responses after administration of ghrelin and/or positive correlations with plasma ghrelin levels, and decreased reward responses after administration of GLP-1 agonists and/or negative correlations with plasma GLP-1 levels