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Your Guide to Planning Pregnancy While Taking Semaglutide, Tirzepatide, or Liraglutide This comprehensive guide is for anyone taking GLP-1 medications, whos thinking about pregnancy
N Engl J Med 2019;380: 347e57
Genetic variants in the GIPR gene (such as rs1800437) may influence how effectively an individual responds to this dual-receptor mechanism
In the STEP 1 trial published in the New England Journal of Medicine (2021), participants receiving semaglutide 2.4 mg weekly achieved an average weight loss of approximately 15% of body weight over 68 weeks, compared to 2.4% with placebo
The clinical signal is now catching up to what the rodent data has been saying for a decade
These medications also show cardiovascular and renal benefits, such as reducing blood pressure, improving endothelial function, and lowering the risk of cardiovascular events like myocardial infarction and stroke [6][16]
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