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Statistical analysis was calculated by a one-way ANOVA with Newman-Keuls test using GraphPad prism 5.0 (GraphPad Software, SanDiego, CA, USA)

1 Second, the comparison against other GLP-1 drugs: in an analysis of FDA adverse-event reports, semaglutide carried the highest constipation reporting signal of any GLP-1 receptor agonist (reporting odds ratio 6.17), ahead of liraglutide, dulaglutide, and the rest

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