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Published topical skin studies summarized by Schagen included one month of daily thigh application in 20 women, 12-week facial or eye-cream studies in 71 or 41 women, and a 12-week twice-daily Cu-GHK cream study in 67 women [2]

doi:10.1080/13803395.2014.904844CrossRefGoogle ScholarPubMed Zamzow, RM, Ferguson, BJ, Stichter, JP, et al

PMCID: PMC1511567

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2.2 Chronic venous insufficiency Two RDP studies on chronic venous insufficiency have shown another interesting clinical application of Pycnogenol (32, 33) that can be mechanistically explained by its beneficial effects on endothelial function and its anti-inflammatory action (65)

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