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499 A and phosphorylated Tau (p-Tau) neurofibrillary lesions lead to the pathology of neurons that display oxidative damage, impaired Ca2+ processing, reduced DNA repair, dysfunction of lysosomal and mitophagy, all of which have a positive correlation with the age-related NAD + decline

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Both NRPs originally identified as neuronal adhesion molecules, participate in Semaphorin -mediated axonal guidance 318

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